# Publications and evidence

HTML: <https://deepbreath.tech/publications.html>  
Last reviewed: 2026-08-18

Papers, study partnerships, and conference talks that involve Deep Breath B.V.

Deep Breath B.V. (Rotterdam) builds hardware and software for collecting, synchronising, labelling, and analysing high-resolution ICU device data, with a focus on mechanical ventilation and patient–ventilator interaction (PVI/PVA). The research platform is in use. Clinical decision support is not MDR or FDA cleared.

PVI on this site means patient–ventilator interaction, not pleth variability index.

## Peer-reviewed papers

### Let’s get in sync: current standing and future of AI-based detection of patient-ventilator asynchrony

- Type: Review article
- Journal: *Intensive Care Medicine Experimental*, 2025
- Authors: Thijs P. Rietveld, Björn J.P. van der Ster, Abraham Schoe, Henrik Endeman, Anton Balakirev, Daria Kozlova, Diederik A.M.P.J. Gommers, Annemijn H. Jonkman
- **Deep Breath’s role:** Anton Balakirev and Daria Kozlova are authors, affiliated with Deep Breath B.V. The paper is a field review of automated PVA detection, not a Deep Breath product validation. The author group forms the SIREN consortium.
- On this site: <https://deepbreath.tech/publications/lets-get-in-sync.html>
- DOI: <https://doi.org/10.1186/s40635-025-00746-8>
- PubMed: <https://pubmed.ncbi.nlm.nih.gov/40119215/>
- PMC (open access): <https://pmc.ncbi.nlm.nih.gov/articles/PMC11928342/>

### Defining and Measuring Patient–Ventilator Interactions: 10 Fundamental Maxims

- Type: Taxonomy
- Journal: *Respiratory Care*, 2026
- Authors: Eduardo Mireles-Cabodevila, Katerina Vaporidi, Lluís Blanch, Robert L. Chatburn
- **Deep Breath’s role:** Referenced / highlighted in the paper. Deep Breath did not author it. The work proposes a standardised vocabulary and measurement framework for PVI.
- On this site: <https://deepbreath.tech/publications/10-fundamental-maxims.html>
- DOI: <https://doi.org/10.1177/19433654261425219>
- PubMed: <https://pubmed.ncbi.nlm.nih.gov/41913371/>

## Studies and partnerships

### PRoVENT–TRACE — official technology partner

- Network: PROVE Network
- Confirmation: 11 August 2026, Juliana C. Ferreira (University of São Paulo)
- Full name: PRactice Of VENTilation: TRacking Asynchronies and Clinical Endpoints
- **Deep Breath’s role:** Official technology partner. Infrastructure for collection, storage, and analysis of high-resolution mechanical ventilation data, including waveforms for patient–ventilator asynchrony assessment, plus site onboarding and deployment support.
- On this site: <https://deepbreath.tech/publications/provent-trace.html>
- Confirmation letter (PDF): <https://deepbreath.tech/files/provent-trace-confirmation-letter.pdf>

### SIREN — Erasmus MC × Deep Breath

- Funder: Health~Holland, 48 months
- Project code: EMCLSH24018
- Partners: Erasmus MC Intensive Care department and Deep Breath B.V.
- **Deep Breath’s role:** Industry partner and data-science engineering team. The project aims to validate and implement real-time AI-based analytics of ventilator waveforms to detect and mitigate harmful PVA. A validated decision-support system is a project deliverable — it is not a cleared product today.
- On this site: <https://deepbreath.tech/publications/siren.html>
- Health~Holland: <https://www.health-holland.com/project/2024/2024/synergy-respiration-improving-patient-ventilator-interaction-ai-based-monitoring>

## Conference presentations

| Date | Event | What was presented | Deep Breath’s role |
|---|---|---|---|
| 10 Jul 2026 | ORICS Summer 2026, Oxford | Dr Dave Clarke, “How to Build Towards an AI-Enabled ICU,” used Deep Breath as a worked example of trustworthy AI infrastructure in a real ICU. | Technology example, presented by a clinical collaborator (Oxford University Hospitals NHS Foundation Trust) |
| 6 Feb 2026 | ESICM Intensive Care Innovation 2026, Amsterdam | Clinical partners presented high-resolution waveform analytics and AI monitoring on the main stage. | Platform presented by clinical partners |
| 12 Mar 2026 | AdvanceMed | End-to-end platform architecture: BreathBox collection, storage, processing, and interfaces for research, education, and decision support. | Company talk |

Related updates: <https://deepbreath.tech/updates/asynchrony-talk.html>, <https://deepbreath.tech/updates/esicm-2026.html>, <https://deepbreath.tech/updates/platform-architecture.html>

Contact for research collaboration: <https://deepbreath.tech/contact.html> · info@deepbreath.tech